abstract：:In several rodent species social play appears to be necessary for proper deployment of species-specific patterns of aggressive and reproductive behavior. Specifically, in male Syrian hamsters (Mesocricetus auratus), play has been linked to the development of adult aggression. We quantified several types of social play...

journal_title：Brain research

authors： Kyle SC,Burghardt GM,Cooper MA

更新日期：2019-06-01 00:00:00

abstract：:Nesfatin-1, an 82-amino acid peptide encoded by the secreted precursor nucleobinin-2 (NUCB2), exerts potent anorexigenic action independently of leptin signaling. This propensity has propelled this peptide and its analogues as potential anti-obesity drug candidates. However, a more extensive comprehension of its biolo...

journal_title：Brain research

authors： Guillebaud F,Roussel G,Félix B,Troadec JD,Dallaporta M,Abysique A

更新日期：2019-05-15 00:00:00

abstract：:We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...

journal_title：Brain research

authors： Linster C,Escanilla O

更新日期：2019-04-15 00:00:00

abstract：:In the present study we investigated the correlation between radiation-induced metabolic and histopathological changes in the brain under experimental conditions. Adult male Wistar rats received fractionated whole-brain irradiation (fWBI) with a total dose of 40 Gy administered in 5 fractions (dose 8 Gy per fraction) ...

journal_title：Brain research

authors： Bálentová S,Hnilicová P,Kalenská D,Baranovičová E,Muríň P,Bittšanský M,Hajtmanová E,Lehotský J,Adamkov M

更新日期：2019-04-01 00:00:00

abstract：:Diabetes mellitus (DM) may lead to gastrointestinal motility disorders. Rodent models of DM indicate the presence of morpho-functional abnormalities of the enteric nervous system. Here, we evaluated whether experimental DM can cause changes in the excitatory cholinergic fibers, neuronal density, and voltage-gated sodi...

journal_title：Brain research

authors： Brasileiro AD,Garcia LP,de Carvalho da Silva S,Rocha LB,Pedrosa AL,Vieira AS,da Silva VJD,Rodrigues ARA

更新日期：2019-04-01 00:00:00

abstract：:Pericyte coverage on the endothelial tubes leads to the formation of a mature and stable microvessel system, which is critical for brain repair after intracerebral hemorrhage (ICH). We report herein that thrombin promotes pericyte coverage by activating Tie2 and the downstream signaling pathway PI3K/Akt in a rat model...

journal_title：Brain research

authors： Hu E,Hu W,Yang A,Zhou H,Zhou J,Luo J,Wang Y,Tang T,Cui H

更新日期：2019-04-01 00:00:00

abstract：:Fetal exposure to dexamethasone (DEX) alters brain plasticity and cognitive functions during adulthood in a sex-dependent manner. The mechanisms underlying such long-lasting sex-dependent change of prenatal DEX is not well understood. The p73 gene plays an important role in brain development. It encodes for two protei...

journal_title：Brain research

authors： Abul M,Al-Bader MD,Mouihate A

更新日期：2019-03-15 00:00:00

abstract：:We found that local perfusion of COA-Cl (0.1, 0.4, or 1.0 mM) into the dorsal striatum of living mice produced a significant and dose-dependent increase in extracellular DA levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Consistent with in vivo findings, 0.1 and 0.2 mM ...

journal_title：Brain research

authors： Jamal M,Tsukamoto I,Takata M,Ito A,Tanaka N,Miki T,Takakura A,Ameno K,Kubota Y,Konishi R,Kinoshita H

更新日期：2019-03-01 00:00:00

abstract：:Intermediate filament aggregation within motor neurons is a hallmark of ALS pathogenesis. Changes to intermediate filament stoichiometry due to altered mRNA steady-state levels of NEFL, PRPH and INA is thought to drive protein aggregation, yet the exact cause of these changes is unknown. MicroRNAs (miRNAs)-master regu...

journal_title：Brain research

authors： Hawley ZCE,Campos-Melo D,Strong MJ

更新日期：2019-03-01 00:00:00

abstract：:A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that executes the blueprint of embryogenesis across vertebrate and invertebrate species. Here,...

journal_title：Brain research

authors： Chou SJ,Tole S

更新日期：2019-02-15 00:00:00

abstract：:Traumatic brain injury (TBI) affects 2.8 million people annually in the United States, with significant populations suffering from ongoing cognitive dysfunction. Impairments in decision-making can have major implications for patients and their caregivers, often enduring for years to decades, yet are rarely explored in...

journal_title：Brain research

authors： Shaver TK,Ozga JE,Zhu B,Anderson KG,Martens KM,Vonder Haar C

更新日期：2019-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and are considered promising therapeutic targets in several neurodegenerative diseases. A number of PPAR agonists have been shown to have neuroprotective properties in the presence of oxidative stress, neuroinflammatory response, and apoptosis i...

journal_title：Brain research

authors： Lee Y,Cho JH,Lee S,Lee W,Chang SC,Chung HY,Moon HR,Lee J

更新日期：2019-02-01 00:00:00

abstract：:Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain areas of adult brains for replenishing damaged differentiated cells. The loss of the balance between NSC self-renewal and differentiation could lead to tumor formation such as the occurrence of glioblastoma (GBM), the most co...

journal_title：Brain research

authors： Shen F,Song C,Liu Y,Zhang J,Wei Song S

更新日期：2019-02-01 00:00:00

abstract：:Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...

journal_title：Brain research

authors： Walia V,Garg C,Garg M

更新日期：2019-02-01 00:00:00

abstract：:Cholinergic systems modulate synaptic transmission across the neuraxis and play an important role in higher brain function including cognition, arousal and nociception. The anterior cingulate cortex (ACC) is a fundamental brain region for nociception and chronic pain, and receives cholinergic projections mainly from b...

journal_title：Brain research

authors： Koga K,Matsuzaki Y,Migita K,Shimoyama S,Eto F,Nakagawa T,Matsumoto T,Terada K,Mishima K,Furue H,Honda K

更新日期：2019-02-01 00:00:00

abstract：:Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive imp...

journal_title：Brain research

authors： Marshall CA,King KM,Kortagere S

更新日期：2019-01-01 00:00:00

abstract：:Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...

journal_title：Brain research

authors： Prüss H,Kirmse K

更新日期：2018-12-15 00:00:00

abstract：:In recent years estradiol has emerged as a potential regulator of transient receptor potential vanilloid (TRPV) cationic channels in the peripheral tissues and sensory neurons, however, its analogous role in the CNS is poorly understood. TRPV channels modulate Ca2+ signalling, neurotransmission and behaviour, and expr...

journal_title：Brain research

authors： Kumar S,Singh O,Singh U,Goswami C,Singru PS

更新日期：2018-12-15 00:00:00

abstract：:The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in...

journal_title：Brain research

authors： Mikkelsen M,Harris AD,Edden RAE,Puts NAJ

更新日期：2018-12-15 00:00:00

abstract：:Pregabalin is useful for treating neuropathic pain, but known to increase body weight as a side effect. To investigate the mechanism of this increase in body weight, we focused on dopamine in the lateral hypothalamus (LH) and examined the effects of pregabalin on dopamine levels in the LH and food intake. The dopamine...

journal_title：Brain research

authors： Ikeda H,Yonemochi N,Ardianto C,Yang L,Kamei J

更新日期：2018-12-15 00:00:00

abstract：:Dexmedetomidine (Dex) has the neuroprotective effect on cerebral ischemia-reperfusion injury (CIRI). But the mechanism is not yet clear. In this study, we established a model of middle cerebral artery occlusion (MCAO) and treated primary cortical neurons with oxygen glucose deprivation (OGD), followed by Dex treatment...

journal_title：Brain research

authors： Liu C,Fu Q,Mu R,Wang F,Zhou C,Zhang L,Yu B,Zhang Y,Fang T,Tian F

更新日期：2018-12-15 00:00:00

abstract：:The aim of this study is to verify whether anatomical changes occur in the brains of chess players. Besides, it is a potential attempt to evaluate diffusion properties along the tracts due to the diverse situations at anatomical level in different locations; moreover, conventional voxel-based analysis (VBA) has alread...

journal_title：Brain research

authors： Zhou S,Jin L,He J,Zeng Q,Wu Y,Cao Z,Feng Y

更新日期：2018-12-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...

journal_title：Brain research

authors： Mendonça HR,Carvalho JNA,Abreu CA,Mariano de Souza Aguiar Dos Santos D,Carvalho JR,Marques SA,da Costa Calaza K,Martinez AMB

更新日期：2018-12-01 00:00:00

abstract：:Cerebral venous thrombosis (CVT) is a rare form of cerebral stroke that causes a variety of symptoms, ranging from mild headache to severe morbidity or death in the more severe forms. The use of anti-coagulant or thrombolytic agents is the classical treatment for CVT. However, the development of new therapies for the ...

journal_title：Brain research

authors： Rashad S,Niizuma K,Sato-Maeda M,Fujimura M,Mansour A,Endo H,Ikawa S,Tominaga T

更新日期：2018-11-15 00:00:00

abstract：:Evidence from human and animal studies has shown that experiences of early attachment can influence brain development and structure. Adult attachment style develops from early attachment experiences. However, little is known about the relationship between gray matter volume and attachment style. Further, the structura...

journal_title：Brain research

authors： Zhang X,Deng M,Ran G,Tang Q,Xu W,Ma Y,Chen X

更新日期：2018-11-15 00:00:00

abstract：:Repeated cocaine exposure alters medial prefrontal cortex (mPFC) function to allow for enhanced excitatory transmission to the nucleus accumbens and ventral tegmental area (VTA). Previous studies have demonstrated changes in receptor function in the mPFC in animals repeatedly exposed to cocaine that produced increased...

journal_title：Brain research

authors： Steketee JD,Liu K

更新日期：2018-11-01 00:00:00

abstract：:Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...

journal_title：Brain research

authors： Sopp MR,Michael T,Mecklinger A

更新日期：2018-11-01 00:00:00

abstract：:In adult rodents, neuroblasts originating from the subventricular zone migrate tangentially through the rostral migratory stream (RMS) toward the olfactory bulb where they differentiate into interneurons. Neuroblasts in the RMS migrate in chains for a long distance along specifically arranged blood vessels which promo...

journal_title：Brain research

authors： Angelidis A,Račeková E,Arnoul P,Závodská M,Raček A,Martončíková M

更新日期：2018-11-01 00:00:00

abstract：:Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...

journal_title：Brain research

authors： Yin D,Zhou S,Xu X,Gao W,Li F,Ma Y,Sun D,Wu Y,Guo Q,Liu H,Han L,Wang Z,Wang Y,Zhang J

更新日期：2018-11-01 00:00:00

abstract：:The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual var...

journal_title：Brain research

authors： Proshina EA,Savostyanov AN,Bocharov AV,Knyazev GG

更新日期：2018-10-15 00:00:00

abstract：:Dural afferent neurons are implicated in primary headaches including migraine. Although a significant portion of primary afferent neurons innervating the dura are myelinated A-type neurons, previous electrophysiological studies have primarily characterized the functional properties of small-sized C-type sensory neuron...

journal_title：Brain research

authors： Nakamura M,Jang IS

更新日期：2018-10-01 00:00:00

abstract：:Systemic administration of mesenchymal stem cells (MSCs) following cerebral infarction exerts functional improvements. Previous research has suggested potential therapeutic mechanisms that promote neuroprotection and synaptogenesis. These include secretion of neurotrophic factors, remodeling of neural circuits, restor...

journal_title：Brain research

authors： Nagahama H,Nakazaki M,Sasaki M,Kataoka-Sasaki Y,Namioka T,Namioka A,Oka S,Onodera R,Suzuki J,Sasaki Y,Kocsis JD,Honmou O

更新日期：2018-09-15 00:00:00

abstract：:Fulfilled predictions lead to neural suppression akin to repetition suppression, but it is currently unclear if such effects generalize to broader stimulus categories in the absence of exact expectations. In particular, does expecting novelty alter the way novel stimuli are processed? In the present study, the effects...

journal_title：Brain research

authors： Schomaker J,Meeter M

更新日期：2018-09-01 00:00:00

abstract：:Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone that is required for the biogenesis of multiple ribonucleoprotein (RNP) complexes including spliceosomal small nuclear RNPs (snRNPs). Re...

journal_title：Brain research

authors： Beattie CE,Kolb SJ

更新日期：2018-08-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due to genetic, pathological and symptomatic overlap, ALS is now considered a spectrum disease together with frontotemporal dementia (FTD),...

journal_title：Brain research

authors： Starr A,Sattler R

更新日期：2018-08-15 00:00:00

abstract：:The success of neuromodulation therapies, particularly in the brain, spinal cord, and peripheral nerves, has been greatly aided by computational, biophysical models. However, treating gastrointestinal disorders with electrical stimulation has been much less explored, partly because the mode of action of such treatment...

journal_title：Brain research

authors： Barth BB,Shen X

更新日期：2018-08-15 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...

journal_title：Brain research

authors： Li S,Chen X,Mao L,Zahid KR,Wen J,Zhang L,Zhang M,Duan J,Duan J,Yin X,Wang Y,Zhao L,Tang X,Wang X,Xu G

更新日期：2018-08-01 00:00:00

abstract：:Transfer learning is an immanent feature of perceptual learning. Yet, despite the increasingly widespread application of transcranial direct current stimulation (tDCS) to study learning, transfer effects in response to tDCS have not been studied. Therefore, the present study investigated the transfer of tactile acuity...

journal_title：Brain research

authors： Hirtz R,Weiss T,Huonker R,Witte OW

更新日期：2018-06-15 00:00:00

abstract：:In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the lef...

journal_title：Brain research

authors： Jeye BM,MacEvoy SP,Karanian JM,Slotnick SD

更新日期：2018-05-15 00:00:00

abstract：:Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...

journal_title：Brain research

authors： Yamamoto Y,Hosoda K,Imahori T,Tanaka J,Matsuo K,Nakai T,Irino Y,Shinohara M,Sato N,Sasayama T,Tanaka K,Nagashima H,Kohta M,Kohmura E

更新日期：2018-05-15 00:00:00